Working with center pull skeins is best, because your yarn will have the least “exposure” to friction, dust, overly tightened fibers and it will “lay” perfectly into your project.
Another must know contribution by Amy Brewster you do not want to miss:
Amy explains in detail and pictures how to wind your yarn so you can pull from the center as you work.
This is a MUST if you have cats too interested in your work. You then can put the yarn in a teapot or container of choice, so it will not get soiled or spoiled while you work: